In Silico Docking of Forchlorfenuron (FCF) to Septins Suggests that FCF Interferes with GTP Binding
نویسندگان
چکیده
منابع مشابه
In Silico Docking of Forchlorfenuron (FCF) to Septins Suggests that FCF Interferes with GTP Binding
Septins are GTP-binding proteins that form cytoskeleton-like filaments, which are essential for many functions in eukaryotic organisms. Small molecule compounds that disrupt septin filament assembly are valuable tools for dissecting septin functions with high temporal control. To date, forchlorfenuron (FCF) is the only compound known to affect septin assembly and functions. FCF dampens the dyna...
متن کاملOff-target effects of the septin drug forchlorfenuron on nonplant eukaryotes.
The septins are a family of GTP-binding proteins that form cytoskeletal filaments. Septins are highly conserved and evolutionarily ancient but are absent from land plants. The synthetic plant cytokinin forchlorfenuron (FCF) was shown previously to inhibit budding yeast cell division and induce ectopic septin structures (M. Iwase, S. Okada, T. Oguchi, and A. Toh-e, Genes Genet. Syst. 79:199-206,...
متن کاملForchlorfenuron Disrupts SEPT9_i1 Filaments and Inhibits HIF-1
Forchlorfenuron (FCF) is a synthetic plant cytokinin that has been shown to alter yeast and mammalian septin organization. Septins are a highly conserved family of GTP-binding cytoskeletal proteins. Mammalian septins are involved in diverse cellular processes including tumorigenesis. We have been studying the interaction between septin 9 isoform 1 (SEPT9_i1) and hypoxia inducible factor-1α (HIF...
متن کاملA Simple Method for Simultaneous Spectrophotometric Determination of Brilliant Blue FCF and Sunset Yellow FCF in Food Samples after Cloud Point Extraction
Rouhollah Heydari*, Mohammad Hosseini, Mohammad Alimoradi and Sanaz Zarabi Razi Herbal Medicines Research Center, Lorestan University of Medical Sciences PO Bo x 68149-89468, Khorrsamabad, Iran. Young Researchers and Elite Club, Arak Branch, Islamic Azad University, Arak, Iran. Department of Chemistry, Faculty of Sciences, Arak Branch, Islamic Azad University, Arak, Iran. Department of Chemistr...
متن کاملA resonance light-scattering determination of proteins with fast green FCF.
The interaction of Fast Green FCF (FCF) with proteins (including bovine serum albumin (BSA), human serum albumin (HSA), pepsin (Pep) and alpha-chymotrypsin (Chy), and lysozyme (Lys)) was characterized by enhanced resonance light-scattering (RLS) measurements using a common spectrofluorometer. The enhanced RLS signals of FCF by proteins at 279.0 nm were obtained, and the mechanism of the RLS enh...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: PLoS ONE
سال: 2014
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0096390